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KMID : 1101420140460010031
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Korean Journal of Clinical Laboratory Science
2014 Volume.46 No. 1 p.31 ~ p.37
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The Relationship between Oxidative Stress and Oxidative Markers
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Park Shin-Young
Lee Sang-Pyung
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Abstract
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Metabolic syndrome such as, hypertension, diabetes, obesity, dyslipidemia etc are well known lifestyle diseases which threaten a health state. The purpose of this study is to evaluate antioxidant status and reactive oxygen species (ROS) in various stressful conditions. A group of persons (n=28) were enrolled in this study and stress status was evaluated using questionnaire of psychological well-being index (PWI-SF) and hematologic analysis of free oxygen radical defense (FORD), free oxygen radical test (FORT), lipid profiles and serum cortisol level. Analysis was done according to stress index, BMI status and overtime working. Blood samples from diabetics were used for control. Results are as in followings: Higher PWI-SF group showed higher FORT. Obese persons with BMI＞ 25 kg/m2 showed statistically lower FORD (p＜0.05) and higher FORT level (p＜0.01). When compare with diabetics, an overweight group had similar levels in FORD and FORT while a normal body weight group showed quite different with diabetics in FORD (p＜0.001). Higher ROS group has higher triglyceride, CRP and insulin levels but lower in FORD and HDL-cholesterol levels. Overtime working at night showed no meaningful result against our expectations. These results suggested that obesity showed most unfavorable correlations in an antioxidant status in various situations.
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KEYWORD
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Oxidative stress, Obesity, Metabolic syndrome, FORD, FORT
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